We've seen huge changes in Battleship, Carrier and Cruiser changes in APOD, namely:

HMS Vanguard plus 2 Lion Class Battleships (I still question the former but still)

Much earlier Implacable class, cancellation of the Audacious, and 4 Malta Class.

What about destroyers?

Keep in mind that HMS Savage (Commissioned 1942) was fitted with 4.5 " HA/LA (DP) guns.
With the extra resources & capacity, is it possible that the entire S Class onward
are armed in this manner, giving the UK a fleet destroyer with effective AA armament two years early.

Or if we go back earlier ...

Due to the War Emergency Programme British destroyer classes until the Battles were based on pre war hulls and
machinery etc and given whatever armament was available. In APOD most of the other Emergency programmes are
squelched early on. If we assume that there is no War Emergency programme then surely British destroyers designs will be different from
OTL, especially with the increase in industrial capacity, perhaps with the Tribals as a template as a template rather than the J class,
albeit adapting the design for mass production as a fleet detroyer (2 Quad torpedo tubes and 3 twin 4.7 inch turrets to begin with)